A new study constructs the first 3D single-cell brain atlas of the lamprey, uncovering the 450-million-year-old molecular blueprint of vertebrates.

Discover why animal models fall short in AI drug discovery and how human-first datasets and functional genomics are changing ...

One of the most detailed maps to date of meningioma, the most common brain tumor in adults, reveals how the tumor’s ...

无颌脊椎动物七鳃鳗的大脑相对简单，了解其工作原理可能为脊椎动物大脑进化提供宝贵见解。研究者结合单核RNA测序和空间转录组学技术，构建了成年七鳃鳗大脑的三维图谱。

Study: Common polyethylene microplastics may worsen fatty liver disease. In mice on high-fat diets, exposure doubled liver ...

Over the past decade, the Human Cell Atlas community has accomplished something that will define a generation of biology.

A new study has uncovered how antidepressants affect different groups of serotonin-producing brain cells in opposite ways, offering new insights into why selective serotonin reuptake inhibitors (SSRIs ...

Scientists have created a comprehensive map of smell receptors in the mouse nose, revealing a few surprises about this fundamental sense. Smell receptors, or olfactory receptors, were previously ...

Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...

A large-scale effort to map epigenetic changes in the aging brain is offering an unprecedented view into how molecular processes evolve over time. By integrating multiple layers of genomic and spatial ...

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...

Latest: v0.3.2 — hierarchical class fallback (class_df, #14) and a major perf fix for doublet mode at K>16 on Hopper/Blackwell GPUs (8h+ stall → ~47 min on K=78, 100k pixels). See CHANGELOG.md. A ...